Abstract: This article introduces the effects of natural gas desulfurization on production in No. 3 Oil Production Plant,SINOPEC Northwest Company. With the increasing of gas processing volume, the environment temperature of the area is rising, and the content of hydrogen sulfide in natural gas is excessive, hence the tube bundle of gas cooler frequently occurs. We compared several previous desulfurization methods and optimized desulfurization technique. Refrigeration technique can cool raw gas and lean liquid, and improve desulfurization effect, which guarantees product quality and the safe operation of processing system.